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Retrospective data analysis of Hospice of the Valleys patients pre and post symptom-targeted reflexology using the palliative care outcome scale (POS-S) evaluation tool. Adult patients with any condition at all phases with a palliative diagnosis, living in Blaenau Gwent (Wales, UK) were included in the study. Mean symptom difference (MSD) and percentage response (PR) were calculated for each symptom. Placebo adjusted response (PAR) was calculated (PR-40%) with PAR of 20% or above being considered significant.